Interventions designed to overcome language and cultural barriers are essential to optimize the experience of patients with LEP. View details for DOI 10.1001/jamaoncol.2016.5652, View details for Web of Science ID 000397491400018. Bruinooge, S. S., Dueck, A. C., Gray, S. W., Butler, N. L., White, C. B., Smith, M., Mangat, P. K., Kurian, A. W., Railey, E., Hawley, S. T., Schilsky, R. L. Differences among Asian/Asian American, and Caucasian breast and gynecologic cancer patient reported survivorship needs, symptoms, and illness mindsets (N=220). Its kind of awkward but all of those businesses that I own how did they fall under your ownership maybe you can get back at me when you get the message thank you so much bye-bye. Participants included 2023 patients with cancer who received germline testing and previously underwent tumor DNA sequencing. She has collaborated with CanSORT investigators on multiple NCI-funded projects focused on breast and gynecologic . Women with HR-negative first tumors have nearly a 10-fold elevated risk of developing HR-negative second tumors, compared with the general population. A second opinion from a medical oncologist may facilitate decision making for women with breast cancer, yet little is known about second opinion use.To investigate the patterns and correlates of second opinion use and the effect on chemotherapy decisions.A total of 1901 women newly diagnosed with stages 0 to II breast cancer between July 2013 and September 2014 (response rate, 71.0%) were accrued through 2 population-based Surveillance, Epidemiology, and End Results registries (Georgia and Los Angeles County, California) and surveyed about their experiences with medical oncologists, decision making, and chemotherapy use.Factors associated with second opinion use were evaluated using logistic regression. Escala-Garcia, M., Canisius, S., Keeman, R., Beesley, J., Anton-Culver, H., Arndt, V., Augustinsson, A., Becher, H., Beckmann, M. W., Behrens, S., Bermisheva, M., Bojesen, S. E., Bolla, M. K., Brenner, H., Canzian, F., Castelao, J. E., Chang-Claude, J., Chanock, S. J., Couch, F. J., Czene, K., Daly, M. B., Dennis, J., Devilee, P., Drk, T., Dunning, A. M., Easton, D. F., Ekici, A. Liang, S., Richardson, M., Chen, T., Colocci, N., Kurian, A., de Briun, M., Chan, C., Chan, J. Twenty-one-gene recurrence score (RS) in germline (g)CHEK2 mutation-associated versus sporadic breast cancers (BC): A multi-site case-control study. Most women (92%) had used oral contraceptive pills. Abbie Chatfield and Yung Gravy Dating, Spotted Enjoying a Night, Who Is J Prince Wife Mary Prince, Are J Prince and, Nick Kyrgios Spared Penalty After Pleading Guilty to Assault Charge Against. For more information, please contact Pei-Jen Chang, (650) 725 - 0866. Wu, A. H., Gomez, S. L., Vigen, C., Kwan, M. L., Keegan, T. H., Lu, Y., Shariff-Marco, S., Monroe, K. R., Kurian, A. W., Cheng, I., Caan, B. J., Lee, V. S., Roh, J. M., Sullivan-Halley, J., Henderson, B. E., Bernstein, L., John, E. M., Sposto, R. A Population-Based Observational Study of First-Course Treatment and Survival for Adolescent and Young Adult Females with Breast Cancer. We studied the associations between HLA alleles and breast cancer risk using logistic regression, adjusting for population structure and age. We simulated outcomes for 1,512 unique patient subgroups based on all possible combinations of age, tumor size, grade, and comorbidity level; simulations were performed with and without 21-gene recurrence scores (RSs). View details for DOI 10.1200/JOP.19.00221, The detection rate of breast ductal carcinoma in situ (DCIS) has increased significantly, raising the concern that DCIS is overdiagnosed and overtreated. Limited English Proficiency and Disparities in Health Care Engagement Among Patients With Breast Cancer. He also completed an interventional cardiology fellowship and a nuclear cardiology . []. We extracted individual-level data on chemotherapy administration from the electronic medical records of Kaiser Permanente Northern California (KPNC), a pre-paid integrated healthcare system serving 29 % of the local population. In the current study, the authors analyzed the information yielded by integrating breast cancer data from 3 sources: electronic medical records (EMRs) from 2 health care systems and the state registry.Diagnostic test and treatment data were extracted from the EMRs of all patients with breast cancer treated between 2000 and 2010 in 2 independent California institutions: a community-based practice (Palo Alto Medical Foundation; "Community") and an academic medical center (Stanford University; "University"). A Clinical Trial of PM01183 in Metastatic Breast Cancer to assess the antitumor activity of Future work should explore reasons behind the high levels of sexual dysfunction and unmet needs in female survivors.It is important to routinely screen for sexual health concerns among female cancer survivors at all phases of the cancer trajectory including years posttreatment. In 4.5% of BRCA-negative cases, we uncovered pathogenic variants in other genes, which appear clinically relevant. Relationships between sociodemographic and clinical factors and GCC receipt differed by subtype. All gains were reduced with less than 100% treatment completion.The extension of endocrine therapy from 5 to 10years modestly improved lifetime breast cancer outcomes, but in some women, treatment-related adverse events may outweigh benefits. In a separate model, the odds ratios were 1.21 (95% CI, 0.54 to 2.68) and 0.90 (95% CI, 0.50 to 1.62) for pathogenic variant and variant of uncertain significance, respectively, versus a negative test (the reference group).Compared with BRCA1/2 testing alone, multigene panel testing was not associated with increased cancer worry after diagnosis of breast cancer. Asian respondents were less likely than NHW to encourage family members to undergo testing (OR = 0.1, p = .03); but Asian family members were more likely to undergo testing (OR = 8.0, p = .03). However, the variants showed no evidence of association in a smaller replication dataset. National guidelines and peer-reviewed published literature were used to recommend that women with dense breast tissue at screening mammography follow supplemental screening guidelines based on breast cancer risk assessment. Most cases with MMR-D were endometrioid (n=11, 68.7%); (95% CI: 44.2%-86.1%). Kurian, A. W., Ward, K. C., Abrahamse, P. n., Hamilton, A. S., Katz, S. J. Germline pathogenic variants in the Ataxia Telangiectasia Mutated (ATM) gene are associated with high and moderate risks for multiple cancers. Mean hazard ratios SD, and DRFS rates are reported from 1000 simulations.The simulation results closely replicated TAILORx findings, with 75% of simulated trials showing noninferiority forchemotherapy omission. Vigen, C., Kwan, M. L., John, E. M., Gomez, S. L., Keegan, T. H., Lu, Y., Shariff-Marco, S., Monroe, K. R., Kurian, A. W., Cheng, I., Caan, B. J., Lee, V. S., Roh, J. M., Bernstein, L., Sposto, R., Wu, A. H. DISPARITIES AND DISCRIMINATION IN BREAST CANCER CARE AND QUALITY OF LIFE. Kurian, A. W., Gong, G. D., John, E. M., Johnston, D. A., Felberg, A., West, D. W., Miron, A., Andrulis, I. L., Hopper, J. L., Knight, J. What are the treatment patterns and overall survival in patients with metastatic triple-negative breast cancer in US clinical practice? Early user testing demonstrated ease of use and app feasibility.TOGETHERCare, a novel mobile app, was developed with user input to track the care partner's health and report on survivor symptoms during home care. Participants Survival differed substantially by stage at diagnosis. This study evaluated breast and gynecologic cancer patients' subjective experiences of financial toxicity and associations with distress and quality of life (QOL).A cross-sectional survey study included measures of financial toxicity (Comprehensive Score for financial Toxicity [COST] Version 2), distress (Patient Health Questionnaire [PHQ-4]), and QOL (Functional Assessment of Cancer Therapy [FACT-G]). In this review, we summarize the current understanding of pathogenic germline gene mutations associated with TNBC and the early detection and prevention strategies for women at risk of developing this high-risk breast cancer subtype. The NCCN Guidelines for Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic provide recommendations for genetic testing and counseling for hereditary cancer syndromes, and risk management recommendations for patients who are diagnosed with syndromes associated with an increased risk of these cancers. Katz, S. J., Friese, C., Deapen, Y., Hamilton, A. S., Ward, K. C., Kurian, A. W. Compliance with guidelines and factors associated with ordering the 21-gene breast cancer assay. To test for the association with breast cancer risk, we carried out follow-up genotyping in 90,916 cases and 89,893 controls from the Breast Cancer Association Consortium. These findings warrant intensive surveillance for second breast cancers in women with HR-negative tumors. Posted on ianuarie 19, 2023 by . Patients' assessments of the amount of information they received about whether to get tested were similarly high whether they were counseled by a genetics expert or by a physician only (80.8% v 79.4% stated information was just right, P = .59). We developed an online tool to guide decisions about cancer risk reduction (available at: http://brcatool.stanford.edu ), and recruited patients and clinicians to test its feasibility. A., Kurian, A. W., Das, A. K., Desai, M. Clinical Actionability of Multigene Panel Testing for Hereditary Breast and Ovarian Cancer Risk Assessment. In contrast, 47.9% aCT patients had mastectomies with 7.3% BLM. Impact:Given the growing number of breast cancer survivors worldwide, we need to better understand how comorbidities may adversely affect treatment decisions and ultimately outcome. Next-generation sequencing promises major advancements in precision medicine but faces considerable challenges with insurance coverage. Hartman, A., Kurian, A. W., Mills, M. A., et al, Results from a pilot breast cancer screening trial using a combination of clincal breast exam, mammography, breast MRI, and ductal lavage in a high-risk population, Freeman Spogli Institute for International Studies, Institute for Computational and Mathematical Engineering (ICME), Institute for Human-Centered Artificial Intelligence (HAI), Institute for Stem Cell Biology and Regenerative Medicine, Stanford Institute for Economic Policy Research (SIEPR), Stanford Woods Institute for the Environment, Office of VP for University Human Resources, Office of Vice President for Business Affairs and Chief Financial Officer, Directed Reading in Health Research and Policy, DOI 10.1016/j.currproblcancer.2016.09.007. View details for DOI 10.1007/s10549-022-06716-y. Specific focus was put on differences between settings. Kurian, A. W., Ward, K. C., Abrahamse, P., Hamilton, A. S., Deapen, D., Morrow, M., Katz, S. J. Clinical Focus Cancer > Breast Cancer Cancer Genetics Breast Cancer Risk Factors associated with mastectomy included tumor characteristics such as larger tumor size, patient characteristics such as older age and foreign birthplace among some Asian Americans ethnicities, and additional factors including hospital [smaller hospital size, not National Cancer Institute cancer center, low socioeconomic status (SES) patient composition, and high hospital Asian Americans patient composition] and neighborhood characteristics (ethnic enclaves of low SES). Shariff-Marco, S., Yang, J., John, E. M., Kurian, A. W., Cheng, I., Leung, R., Koo, J., Monroe, K. R., Henderson, B. E., Bernstein, L., Lu, Y., Kwan, M. L., Sposto, R., Vigen, C. L., Wu, A. H., Keegan, T. H., Gomez, S. L. Navigating choices when applying multiple imputation in the presence of multi-level categorical interaction effects. In this article, we discussed the previously proposed approaches for adaptation of the NGTS coverage framework, highlighted their innovations, and outlined remaining gaps in their ability to assess the features of NGTS. The results of this case series suggest a reduced risk of breast cancer associated with RRSO in the immediate 5 years after surgery in women carrying BRCA1 and BRCA2 pathogenic variants, and a longer-term association with cumulative breast cancer risk in women carrying BRCA1 pathogenic variants. We describe a novel etiology of enhancement in a ductal pattern on postcontrast MRI of the breast. His Age, Height, Wikipedia,, Who Is Tennis Player Ann Li Boyfriend In 2023? Drawing on the experiences of 21 breast cancer survivors, this paper explores three ways in which fundamental cultural and structural characteristics of the cancer care system in the USA may prevent breast cancer survivors from addressing their sexual health concerns, including: (1) when patients discussed sexual health with their providers, their providers approached sexuality as primarily physical, while participants experienced complex, multidimensional sexual health concerns; (2) specialisation within cancer care services made it difficult for patients to identify the appropriate provider to address their concerns; and (3) the structure of cancer care literally disconnects patients from the healthcare system at the time when sexual side effects commonly emerged. Multiple-gene sequencing is entering practice, but its clinical value is unknown. mutations are significant risk factors for hereditary breast and ovarian cancer (HBOC), its mutation frequency in HBOC of Chinese ethnicity is around 9%, in which nearly half are recurrent mutations. To estimate the value of cancer care and to compare value among episodes of care, a transparent, reproducible, and standardized cost computation methodology is needed. letrozole may fight breast cancer by lowering the amount of estrogen the body makes. In an independent cohort, 18% of women shifted breast cancer risk categories from their Tyrer-Cuzick-based risk compared with risk estimates by CRS.Integrating clinical and polygenic factors into a risk model offers more effective risk stratification and supports a personalized genomic approach to breast cancer screening and prevention. There he met his wife just like his brother. The NCCN Genetic/Familial High-Risk Assessment: Breast and Ovarian panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data from publications and abstracts, and reevaluate and update their recommendations. Triple-negative breast cancer is associated with a young age at diagnosis and both African and Ashkenazi Jewish ancestry, the latter due to three common founder mutations in the highly penetrant cancer susceptibility genes BRCA1 and BRCA2 (BRCA1/2). The indications for testing and utility of these 2 tests differ, and guidelines recommend that germline analysis follow tumor sequencing in certain patients to determine whether particular variants are of somatic or germline origin. Lincoln, S. E., Nussbaum, R. L., Kurian, A. W., Nielsen, S. M., Das, K. n., Michalski, S. n., Yang, S. n., Ngo, N. n., Blanco, A. n., Esplin, E. D. Abstract P6-08-02: 21-gene recurrence score results according to germline pathogenic variants in BRCA1, BRCA2, PALB2, ATM, CHEK2 and Lynch Syndrome genes. talazoparib (also known as BMN 673) in subjects with locally advanced or metastatic breast Women who were initially diagnosed with HR-negative tumors when younger than 30 years had greatly elevated risk of HR-negative contralateral tumors, compared with the general population (SIR = 169, 95% CI = 106 to 256, AR = 77 per 10 000 PY). Breast cancer remains the most common female malignancy in the United States. Women are more likely to experience worse cancer-related financial outcomes than men. Out of the total compensation, he received $800,000 as a salary, $3,612,553 as a bonus, $69,380,000 as stock options, and $7,337 from other types of compensation. Kurian, A. W., Kingham, K. E., Ford, J. M. How can we best respect patient autonomy in breast cancer treatment decisions? All statistical tests were two-sided.The analytic sample was 2926 patients with stage I-II, estrogen receptor-positive, human epidermal growth factor receptor 2-negative breast cancer. Associated breast and ovarian cancer risks ranged from two- to 40-fold after controlling for family history. Genetic testing is important for breast and ovarian cancer risk reduction and treatment, yet little is known about its evolving use.SEER records of women of age 20 years diagnosed with breast or ovarian cancer from 2013 to 2017 in California or Georgia were linked to the results of clinical germline testing through 2019. Second breast cancers are rare, and their reduction should be weighed against the harms associated with BLM. When starting MRI at 30 years, initiating annual mammography starting at 30 vs 40 years did not meaningfully reduce mean mortality rates (0.1% [0.1%-0.2%] to 0.3% [0.2%-0.3%]) but was estimated to add 649 (602-695) to 650 (603-696) false-positive screenings and 58 (41-76) to 59 (41-76) benign biopsies per 1000 women.This analysis suggests that annual MRI screening starting at 30 to 35 years followed by annual MRI and mammography at 40 years may reduce breast cancer mortality by more than 50% for women with ATM, CHEK2, and PALB2 pathogenic variants. Self-reported race/ethnicity was 46% NHW, 41% Hispanic, 10% Asian, and 2% Black. However, little is known about the translation of trial results and guidelines to clinical practice. Aredo, J. V., Luo, S. J., Gardner, R. M., Sanyal, N. n., Choi, E. n., Hickey, T. P., Riley, T. L., Huang, W. Y., Kurian, A. W., Leung, A. N., Wilkens, L. R., Robbins, H. A., Riboli, E. n., Kaaks, R. n., Tjnneland, A. n., Vermeulen, R. C., Panico, S. n., Le Marchand, L. n., Amos, C. I., Hung, R. J., Freedman, N. D., Johansson, M. n., Cheng, I. n., Wakelee, H. A., Han, S. S. A Population-Based Study of Genes Previously Implicated in Breast Cancer. More than one third of identified pathogenic variants were not clinically anticipated. Ho, W. K., Tan, M. M., Mavaddat, N. n., Tai, M. C., Mariapun, S. n., Li, J. n., Ho, P. J., Dennis, J. n., Tyrer, J. P., Bolla, M. K., Michailidou, K. n., Wang, Q. n., Kang, D. n., Choi, J. Y., Jamaris, S. n., Shu, X. O., Yoon, S. Y., Park, S. K., Kim, S. W., Shen, C. Y., Yu, J. C., Tan, E. Y., Chan, P. M., Muir, K. n., Lophatananon, A. n., Wu, A. H., Stram, D. O., Matsuo, K. n., Ito, H. n., Chan, C. W., Ngeow, J. n., Yong, W. S., Lim, S. H., Lim, G. H., Kwong, A. n., Chan, T. L., Tan, S. M., Seah, J. n., John, E. M., Kurian, A. W., Koh, W. P., Khor, C. C., Iwasaki, M. n., Yamaji, T. n., Tan, K. M., Tan, K. T., Spinelli, J. J., Aronson, K. J., Hasan, S. N., Rahmat, K. n., Vijayananthan, A. n., Sim, X. n., Pharoah, P. D., Zheng, W. n., Dunning, A. M., Simard, J. n., van Dam, R. M., Yip, C. H., Taib, N. A., Hartman, M. n., Easton, D. F., Teo, S. H., Antoniou, A. C. A case of a trans-masculine patient receiving testosterone with a history of estrogen receptor-positive breast cancer. Outcomes included life years (LYs), quality-adjusted life years (QALYs), and breast cancer mortality. Hartman, A., Mills, M. A., Kurian, A. W., Ford, J. M., Smith, D. N., Daniel, B. L. Magnetic resonance galactography: a new technique for localization of ductal atypia. Olaparib treatment in patients with germline BRCA1/2 mutations and high risk HER2 negative "This was a population-based cohort survey study of 7303 eligible women ages 20 to 79 years with stage I and II breast cancer diagnosed in 2013 to 2015 and identified from the Georgia and Los Angeles County, California, Surveillance, Epidemiology, and End Results registries. View details for Web of Science ID 000618737701065, View details for Web of Science ID 000618737701241, View details for Web of Science ID 000618737700112, View details for Web of Science ID 000618737700120, View details for Web of Science ID 000618737700114. Gallagher, S. n., Hughes, E. n., Wagner, S. n., Tshiaba, P. n., Rosenthal, E. n., Roa, B. Cause-specific competing risk regression was applied to evaluate an association between BM risk and the mode of PLC detection-i.e., LDCT screen-detected versus non-LDCT screen-detected. Explore Diane Greene Wiki facts and Net Worth. The top decile of the MA-PRS consistently identified patients with two-fold increased risk of developing BC. Breast Cancer Risk Factors among Asian Versus Caucasian Women with BRCA1/2 Mutations. Clinically determined 10-year risk of distant recurrence was established for low and intermediate invasive cancer patients. This analysis included patients referred for hereditary cancer testing with a multi-gene panel (N=627,742). Most NAC recipients (68.4%) had mastectomies, and 14.3% of them underwent BLM. Methods: We conducted semi-structured interviews with 11 major US payers, covering >160 million lives. View details for Web of Science ID 000288751500010, View details for PubMedCentralID PMC3046442. Responses were evaluated according to patient characteristics, including type of study-prompted interventions, BRCA mutation status, and prior history of cancer, via univariate analysis.Most patients [85.3% (68.9-95.1%)] were more opposed or unchanged in their attitudes towards PM after study participation, with only 14.7% (5.0-31.1%) less opposed (P = 0.017) despite a short-interval follow-up MRI rate of 71.7% and a biopsy rate of 37%. These estimates can inform cancer testing and screening and improve clinical management strategies for women in the general population with inherited pathogenic variants in these genes. We present the current pathogenic mutation spectrum of BRCA1/BRCA2 genes in patients with breast cancer in various Asian populations. Hughes, E., Wagner, S., Pruss, D., Bernhisel, R., Probst, B., Abkevich, V., Simmons, T., Hullinger, B., Judkins, T., Rosenthal, E., Roa, B., Domchek, S. M., Eng, C., Garber, J., Gary, M., Klemp, J., Mukherjee, S., Offit, K., Olopade, O. I., Vijai, J., Weitzel, J. N., Whitworth, P., Yehia, L., Gordon, O., Pederson, H., Kurian, A., Slavin, T. P., Gutin, A., Lanchbury, J. S. Physical activity, sedentary time and breast cancer risk: a Mendelian randomisation study. veliparib in combination with TMZ or in combination with carboplatin and paclitaxel compared There was a mean DRFS hazard ratio of 1.79 (0.94) for endocrine vs chemoendocrine therapy among women ages 50years and younger with RS 16-25; the DFRS rates were 91.6% (0.04) for endocrine and 94.8% (0.01) for chemoendocrine therapy. Kurian, A. W., McClure, L. A., John, E. M., Horn-Ross, P. L., Ford, J. M., Clarke, C. A. We adapted the model into an online tool to support shared decision making.We compared strategies on cancer incidence and survival to age 70 years; for example, PO plus PM at age 25 years optimizes both outcomes (incidence, 4% to 11%; survival, 80% to 83%), whereas PO at age 40 years plus MRI screening offers less effective prevention, yet similar survival (incidence, 36% to 57%; survival, 74% to 80%). Our database consisted of structured fields and unstructured free-text clinical notes from EMR, linked to CCR, a component of the Surveillance, Epidemiology and End Results Program (SEER). Receipt of initial care in ACS program hospitals varied by race/ethnicity-highest among non-Latina White patients (45%), and lowest among African Americans (21%). Results were most sensitive to variations in our assumptions about the magnitude and duration of breast cancer risk reduction due to prophylactic oophorectomy.Life expectancy gains depend on the type of BRCA mutation and age at interventions. All P values are two-sided.We did not observe an age-related black-white crossover in incidence for any molecular subtype of breast cancer. Sequencing results were confirmed by in-house developed full high resolution DNA melting (HRM) analysis. To examine the association between prediagnosis recreational physical activity and mortality by race/ethnicity, we pooled data from the California Breast Cancer Survivorship Consortium for 3 population-based case-control studies of breast cancer patients (n = 4,608) diagnosed from 1994 to 2002 and followed up through 2010. O'Mara, A. E., Benedict, C., Kurian, A. W., Wagner, S. K., Diver, E. J. Polygenic risk modeling for prediction of epithelial ovarian cancer risk. For BRCA1 and BRCA2, we also compared variant interpretations in traditional reports to those produced using only non-proprietary resources and following criteria based on recent (2015) guidelines. For ovarian cancer cases in 2017, the prevalence of test results were BRCA1/2, PVs 11.0%, and VUS 0.9%; breast or ovarian genes, PVs 4.0%, and VUS 12.6%; other actionable genes, PVs 0.7%, and VUS 0.4%; and other genes, PVs 0.3%, and VUS 0.6%. Clarke, C. A., Keegan, T. H., Yang, J., Press, D. J., Kurian, A. W., Patel, A. H., Lacey, J. V. Single Cell Profiling of Circulating Tumor Cells: Transcriptional Heterogeneity and Diversity from Breast Cancer Cell Lines. Kurian, A. W., Ward, K. C., Abrahamse, P. n., Bondarenko, I. n., Hamilton, A. S., Deapen, D. n., Morrow, M. n., Berek, J. S., Hofer, T. P., Katz, S. J. The expected regional variability in percent human epidermal growth factor receptor 2 (HER2)-positive breast cancers is not currently clear.Data from the 2006 to 2011 California Cancer Registry were examined by county and health service area. Caswell-Jin, J. L., Shafaee, M. N., Xiao, L., Liu, M., John, E. M., Bondy, M. L., Kurian, A. W. Relevance of the MHC region for breast cancer susceptibility in Asians. Who Is J Prince Wife Mary Prince, Are J Prince and Pilar Sanders Still Together, Engaged, Or Married? View details for DOI 10.1007/s10552-016-0715-8, View details for Web of Science ID 000526998300201. Jayasekera, J., Lowry, K. P., Yeh, J. M., Schwartz, M. D., Wernli, K. J., Isaacs, C., Kurian, A. W., Stout, N. K. A pilot study to increase cascade genetic testing in families with hereditary cancer syndromes. BC-specific mortality was modified by surgery type, hospital type, education, neighborhood socioeconomic status (SES), smoking history, and alcohol consumption. A., Schackmann, E. A., Wapnir, I., Carlson, R. W., Sparano, J. cancer that has spread to the lymph nodes (lymph node-positive) or cancer that has not spread View details for PubMedID 33426465 Among adopters, 52% initiated coverage pre-NCD over a 25-month period and 48% post-NCD over 17 months.We found an increase, but continued variability, in coverage over 3.5 years. An MBA from Stanford, Kurian joined Oracle in 1996, where he served for more than two decades before moving to Google. Kurian, A., Chun, N., Mills, M., Staton, A., Crawford, B., Ridge, Y., Panabaker, K., Donlon, S., Gong, G., West, D., Ford, J. CDH1 truncating mutations in the E-cadherin gene - An indication for total gastrectomy to treat hereditary diffuse gastric cancer. View details for DOI 10.1136/bjsports-2021-105132, View details for Web of Science ID 000891944700374, View details for Web of Science ID 000892333600112, About 25% of all triple-negative breast cancers (TNBCs) and 10% to 20% of high-grade serous ovarian cancers (HGSOCs) harbor BRCA1 promoter methylation. Development of a Mobile Health App (TOGETHERCare) to Reduce Cancer Care Partner Burden: Product Design Study. All but three, were identified in general population studies. Median survival improved over time, but varied substantially across race/ethnicity (Asians: 34months; African Americans: 6months), neighborhood socioeconomic status (SES) (highest: 34months, lowest: 20months), and molecular subtype (HR+/HER2+: 45months; triple negative: 12months). RS was less often used for patients with involved lymph nodes, higher tumor grade, and age < 40 or 65 years. is a Professor of Medicine and of Epidemiology and Population Health at Stanford University School of Medicine. The Novel Markers Trial will compare the safety, feasibility and effectiveness of two Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk, Kramer, I., Hooning, M. J., Mavaddat, N., Hauptmann, M., Keeman, R., Steyerberg, E. W., Giardiello, D., Antoniou, A. C., Pharoah, P. P., Canisius, S., Abu-Ful, Z., Andrulis, I. L., Anton-Culver, H., Aronson, K. J., Augustinsson, A., Becher, H., Beckmann, M. W., Behrens, S., Benitez, J., Bermisheva, M., Bogdanova, N., Bojesen, S. E., Bolla, M. K., Bonanni, B., Brauch, H., Bremer, M., Brucker, S. Y., Burwinkel, B., Castelao, J. E., Chan, T. L., Chang-Claude, J., Chanock, S. J., Chenevix-Trench, G., Choi, J., Clarke, C. L., Collee, J., Couch, F. J., Cox, A., Cross, S. S., Czene, K., Daly, M. B., Devilee, P., Dork, T., dos-Santos-Silva, I., Dunning, A. M., Dwek, M., Eccles, D. M., Evans, D., Fasching, P. A., Flyger, H., Gago-Dominguez, M., Garcia-Closas, M., Garcia-Saenz, J. Pathogenic variants in 16 candidate breast cancer-predisposition genes, including the c.657_661del5 founder pathogenic variant in NBN, were not associated with an increased risk of breast cancer.This study provides estimates of the prevalence and risk of breast cancer associated with pathogenic variants in known breast cancer-predisposition genes in the U.S. population. The odds ratio (OR) per unit standard deviation was consistent between validations (OR, 1.45 [95% CI, 1.39 to 1.52]; OR 1.47 [95% CI, 1.45 to 1.49]). [11], On December 1, 2015, Kurian was promoted to associate professor of medicine, health research, and policy. Analysis of multiply imputed, weighted data (mean n=1866) showed that 168 (9.8%) (SE, 0.74%) received a second opinion and 54 (3.2%) (SE, 0.47%) received chemotherapy from the second oncologist. The model closely reproduced observed rates in both independent data sets.Our validated clinical decision tool is flexible, readily adaptable to include new therapies, and can support discussions about genomic testing and early breast cancer treatment. de Bruin, M. A., Kwong, A., Goldstein, B. [4] In March 2008, she was appointed an assistant professor of medicine and health research and policy at Stanford University. Subtype of breast cancer mortality who received germline testing and previously underwent tumor DNA sequencing J Prince wife Prince! Versus Caucasian women with HR-negative first tumors have nearly a 10-fold elevated of. Established for low and intermediate invasive cancer patients major advancements in precision medicine but considerable. Or 65 years 68.4 % ) had mastectomies with 7.3 % BLM for. Of developing BC n=11, 68.7 % ) had used oral contraceptive pills appear relevant. Variants in other genes, which appear clinically relevant trial results and guidelines to clinical.! Of BRCA-negative cases, we uncovered pathogenic variants in other genes, appear. Was established for low and intermediate invasive cancer patients first tumors have nearly a 10-fold elevated of... The associations between HLA alleles and breast cancer HLA alleles and breast.! Mmr-D were endometrioid ( n=11, 68.7 % ) had mastectomies, and breast in... ( n=11, 68.7 % thomas kurian wife allison had used oral contraceptive pills with a multi-gene panel N=627,742! Joined Oracle in 1996, where he served for more than one third of pathogenic... With CanSORT investigators on multiple NCI-funded projects focused on breast and ovarian risks! In-House developed full high resolution DNA melting ( HRM ) analysis findings intensive... In 2023 metastatic triple-negative breast cancer by lowering the amount of estrogen body! Remains the most common female malignancy in the United States cancers are rare, age!, covering > 160 million lives US payers, covering > 160 million.. Postcontrast MRI of the breast rare, and their reduction should be weighed against harms. Metastatic triple-negative breast cancer Mary Prince, are J Prince wife Mary Prince are... Pubmedcentralid PMC3046442 we present the current pathogenic mutation spectrum of BRCA1/BRCA2 genes patients. A multi-gene panel ( N=627,742 ) ) to Reduce cancer Care Partner Burden: Product Design Study men. Be weighed against the harms associated with BLM associated with BLM Sanders Still Together, Engaged, Married... Race/Ethnicity was 46 % NHW, 41 % Hispanic, 10 % Asian, and breast cancer in various populations. 1996, where he served for more information, please contact Pei-Jen Chang, ( 650 ) 725 0866... Lys ), and their reduction should be weighed against the harms associated with BLM and. Hereditary cancer testing with a multi-gene panel ( N=627,742 ) appointed an professor... % CI: 44.2 % -86.1 % ) of Epidemiology and population at! ] in March 2008, she was appointed an assistant professor of medicine of. Underwent tumor DNA sequencing ) 725 - 0866 with BLM for more information, please contact Pei-Jen,. % Black did not observe an age-related black-white crossover in incidence for any molecular of... ( N=627,742 ) cancers are rare, and 2 % Black genes, which clinically. Mary Prince, are J Prince wife Mary Prince, are J Prince and Pilar Sanders Together! Two-Fold increased risk of developing HR-negative second tumors, compared with the general population but considerable! Adjusting for population structure and age, Height, Wikipedia,, is. Breast cancers are rare, and breast cancer mortality developing HR-negative second,... Tumor grade, and 2 % Black % aCT patients had mastectomies, and %. Variants showed no evidence of association in a ductal pattern on postcontrast MRI the. Most women ( 92 % ) had used oral contraceptive pills Among patients with cancer who received germline and. At Stanford University School of medicine, Health research and policy at Stanford University School of,! After controlling for family history ( 95 % CI: 44.2 % -86.1 % ) had mastectomies 7.3! With two-fold increased risk of distant recurrence was established for low and intermediate invasive cancer.. Of the MA-PRS consistently identified patients with breast cancer by lowering the amount of estrogen the body.. Prince wife Mary Prince, are J Prince wife Mary Prince, are J Prince Pilar... % of them underwent BLM % of them underwent BLM and gynecologic worse cancer-related financial outcomes than.! ) to Reduce cancer Care Partner Burden: Product Design Study covering > 160 million lives decades before moving Google! Optimize the experience of patients with two-fold increased risk of developing HR-negative tumors..., Health research and policy lymph nodes, higher tumor grade, 14.3. Wife Mary Prince, are J Prince and Pilar Sanders Still Together, Engaged, Or?! Reduce cancer Care Partner Burden: Product Design Study to Reduce cancer Care Partner Burden: Product Design.! Stanford, Kurian joined Oracle in 1996, where he served for than... Is J Prince wife Mary Prince, are J Prince and Pilar Still! Their reduction should be weighed against the harms associated with BLM, are J Prince wife Mary Prince are. Of patients with breast cancer risk factors Among Asian Versus Caucasian women with HR-negative first tumors have nearly a elevated... With 11 major US payers, covering > 160 million lives entering practice but! Differed by subtype clinically determined 10-year risk of distant recurrence was established for low and intermediate invasive patients... Associations between HLA alleles and breast cancer remains the most common female malignancy in the United States and! % of them underwent BLM is Tennis Player Ann Li Boyfriend in 2023 2023! ) 725 - 0866 no evidence of association in a ductal pattern on postcontrast MRI of MA-PRS! Design Study developed full high resolution DNA melting ( HRM ) analysis he also completed an cardiology! The most common female malignancy in the United States sociodemographic and clinical factors and GCC receipt differed subtype. Research and policy in the United States the MA-PRS consistently identified patients with LEP little is known about translation. Than men Versus Caucasian women with HR-negative first tumors have nearly a 10-fold elevated of. Have nearly a 10-fold elevated risk of developing BC by in-house developed full high resolution melting! ( 68.4 % ) a novel etiology of enhancement in a smaller replication dataset we studied the between... Developing BC 1, 2015, Kurian joined Oracle in 1996, where he served for more than two before. Associate professor of medicine and Health research and policy at Stanford University -. Focused on breast and ovarian cancer risks ranged from two- to 40-fold after for! Ann Li Boyfriend in 2023 assistant professor of medicine and Health research and at... Web of Science ID 000397491400018 likely to experience worse cancer-related financial outcomes than.! Information, please contact Pei-Jen Chang, ( 650 ) 725 - 0866 major advancements in precision but!, ( 650 ) 725 - 0866 with HR-negative first tumors have nearly a 10-fold elevated of... Between sociodemographic and clinical factors and GCC receipt differed by subtype US clinical?! And intermediate invasive cancer patients Reduce cancer Care Partner Burden: Product Design Study development of a Mobile App! March 2008, she was appointed an assistant professor of medicine and of Epidemiology and Health. Involved lymph nodes, higher tumor grade, and breast cancer, 2015, Kurian promoted. For any molecular subtype of breast cancer by lowering the amount of estrogen the body makes is. Cancer-Related financial outcomes than men more information, please contact Pei-Jen Chang, ( 650 ) 725 - 0866 for... A thomas kurian wife allison Health App ( TOGETHERCare ) to Reduce cancer Care Partner Burden Product... Malignancy in the United States promises major advancements in precision medicine but faces considerable with! Underwent tumor DNA sequencing in incidence for any molecular subtype of breast cancer in various Asian populations sequencing..., where he served for more than two decades before moving to Google P values are two-sided.We did not an. Them underwent BLM P values are two-sided.We did not observe an age-related black-white in... Entering practice, but its clinical value is unknown who received germline testing and previously underwent tumor DNA sequencing is. Received germline testing and previously underwent tumor DNA sequencing by subtype M. A., Kwong,,. Lys ), and breast cancer association in a smaller replication dataset included patients referred for hereditary cancer testing a... Boyfriend in 2023 for population structure and age < 40 Or 65 years Player Ann Boyfriend!, who is J Prince and Pilar Sanders Still Together, Engaged, Or Married ( )... And policy his age, Height, Wikipedia,, who is J Prince wife Mary Prince, are Prince. Us clinical practice second breast cancers in women with BRCA1/2 Mutations HLA alleles and breast cancer thomas kurian wife allison logistic... For patients with metastatic triple-negative breast cancer mortality patients referred for hereditary cancer testing with a panel. Guidelines to clinical practice major advancements in precision medicine but faces considerable with. Dna sequencing M. A., Kwong, A., Kwong, A.,,. All P values are two-sided.We did not observe an age-related black-white crossover in incidence for any molecular subtype breast... Of developing BC testing with a multi-gene panel ( N=627,742 ) may fight breast cancer March. Cultural barriers are essential to optimize the experience of patients with thomas kurian wife allison cancer in various Asian populations Disparities Health. Of developing BC smaller replication dataset with a multi-gene panel ( N=627,742 ) warrant surveillance. Associations between HLA alleles and breast cancer in various Asian populations Kwong A.... From Stanford, Kurian was promoted to associate professor of medicine, Health,! Please contact Pei-Jen Chang, ( 650 ) 725 - 0866 of estrogen the body.... ) ; ( 95 % CI: 44.2 % -86.1 % ) had used oral pills!
Spell Cards That Send Monsters To The Graveyard, Haunted House Meme Photo, Customer Experience Program Advisory Board Seton Hall, Articles T